What is engineered probiotics? Engineered probiotics are microorganisms with optimized metabolic processes, typically achieved using synthetic biology and omics technologies. In recent years, genome sequencing has become more affordable and some of the tools for editing and modifying microbial genomes have become more powerful, enable us to engineer probiotics according to our own ideas. By …
According to knowledge of the gut microbiota, the phylogenetic range and characteristics of the organisms are under investigation as novel therapeutics. (Next-generation probiotics) As the microbiota studies proceed, single bacterial strains are screened and isolated, aiming to characterize their relationship with the amelioration of specific diseases. Among these, some of them are expected to emerge …
Gut microbiota is closely related to the host’s health. Pathogenesis of Colorectal Cancer is often accompanied by intestinal microbial dysbiosis. It has been demonstrated that increased abundances of some gut bacteria, including Fusobacterium nucleatum and Peptostreptococcus anaerobius, promotes colorectal carcinogenesis. Now a day, the prevention or treatment of Colorectal Cancer using probiotics has become a …
ادامه خواندن “Use of Engineered Probiotics for Colorectal Cancer Therapy”
The use of antibiotics to fight microbial infections is a cornerstone of modern medicine. However, antibiotics can also disrupt the delicate balance of our gut microbiome, leading to side effects like antibiotic-associated diarrhea (AAD) and potentially contributing to antibiotic resistance. This is where probiotics come in, raising the question: can co-prescribing antibiotics with probiotics be …
ادامه خواندن “Co Prescribing Antibiotics with Probiotics: A Balancing Act in Microbial Infection”
The human intestine is colonized by 10–۱۰۰ trillion commensal bacteria that are involved in the digestion process, modulation of immune response, and other functions. Nowadays, due to excessive use of antibiotics, stress conditions, and hygiene, we encounter gut dysbiosis. Prebiotics Prebiotics are defined as a “substrate that is selectively utilized by host microorganisms conferring a …
ادامه خواندن “The Effects of Prebiotics and Probiotics on Inflammatory Bowel Disease”
MicroRNAs (miRNAs) are short non-coding RNAs comprising 20 to 24 nucleotide bases, which play important roles in all the biological and physiological pathways in multicellular organisms. Figure 1 shows the scheme of miRNA biogenesis. Dysregulation of microRNAs plays an important role in the pathogenesis of many different diseases. These diseases include, central nervous system disorders, …
ادامه خواندن “The effects of probiotics on modulation of microRNAs”
The prevalence of elderly, is expected to double by 2050. Scientific advancements in the prevention and treatment of disease have prolonged human life span however, the increased life span is not accompanied by an elevated health span. Aging is an irreversible biological process that can be defined using nine hallmarks: the deregulation of genetic, epigenetic, …
ادامه خواندن “The Role of Probiotics in the Prevention and Management of Age-Related Diseases”
Introduction Some studies suggest that probiotics are able to overcome insulin resistance in pregnant women with GD by improving lipid metabolism in the gut, increasing glutathione (GSH) levels, and reduction of the inflammatory biomarkers like high sensitive C-reactive protein (hs-CRP) and oxidative stress. Through pregnancy, the inflammatory conditions of the body affect the number of …
Scientific use of probiotics, postbiotics, prebiotics, paraprobiotics and synbiotics can be safe and alternative strategy against microbial infections, particularly in the ongoing and post-pandemic situation. Probiotics are known to promote heath by stimulating native gut microbiota, host immunity, cholesterol reduction and several other functions, whereas their metabolites such as bacteriocins, lactic acid and hydrogen peroxide, …
ادامه خواندن “A mini review on Probiotics, prebiotics, Postbiotcs, Paraprobiotics and synbiotics”
The most accepted definition of probiotics is “live microorganisms which when administered inadequate amounts confer a health benefit on the host”. The health benefits of probiotics on gut microbiome have been previously described. The effects of probiotic can be species-, dose-, and disease-specific. Probiotics have been widely studied in a variety of gastrointestinal diseases. However, …
